تصرّف مسجدالحرام در سال 1349
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بازخوانی اهداف و انگیزه های اشغال مسجدالحرام در سال 1400ق.
چکیده در نخستین روز از ماه محرم سال 1400ق. مسجدالحرام به دست عده‌ای که رهبری آنان را جهیمان العتیبی به عهده دارد، اشغال می‌شود. اینان با شخصی که او را مهدی موعود می‌خوانند، بیعت می‌کنند. در پی رویارویی مسلحانة حکومت با اینان، حادثه با کشتار و خونریزی فراوان همراه می‌شود. پس از یک هفته درگیری، حکومت سعودی به زانو درآمده و ناگزیر، دست به دامن غربی‌ها می‌شود. سرانجام پس از گذش...
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Cytochrome P450 is a family of enzymes that catalyze reactions involved in the metabolism of drugs and other xenobiotics. These enzymes are therefore important in pharmacologic and toxicologic studies, and information on their abundances is of value in the process of scaling in vitro data to in vivo metabolic parameters. A meta-analysis was applied to data on the abundance of human hepatic cyto...
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Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy. Thrombomodulin-dependent APC formation mediates cytoprotection in diabetic neph...
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Miguel Angel Pujana1,2,16,17, Jing-Dong J Han1,2,16,17, Lea M Starita3,16,17, Kristen N Stevens4,17, Muneesh Tewari1,2,16, Jin Sook Ahn1,2, Gad Rennert5, Vı́ctor Moreno6,7, Tomas Kirchhoff 8, Bert Gold9, Volker Assmann10, Wael M ElShamy2, Jean-François Rual1,2, Douglas Levine8, Laura S Rozek6, Rebecca S Gelman11, Kristin C Gunsalus12, Roger A Greenberg2, Bijan Sobhian2, Nicolas Bertin1,2, Kavith...
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In Alzheimer disease, increased b-secretase (BACE1) activity has been associated with neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. In this study, we found that lowering BACE1 levels using lentiviral vectors expressing siRNAs targeting BACE1 reduced amyloid production and the ...
full textDmm021865 1349..1360
A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydroxylase enzymes, which regulate the protein stability of hypoxia-inducible factor α (HIF-α) transcription factors. When stabilised, HIF-α binds with its cofactors to HIFresponsive elements (HREs) in the promoters of target ge...
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volume 13 issue 49
pages 1- 1
publication date 2004-09-22
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